This is the meat & potatoes of the game plan (or the waffles & fried chicken if you're from the ATL) (or rice cakes & nutella if you're some sort of health nut). If you separate the breakout from a specific field layout you quickly discover that most of the standard breakouts apply across all field designs with minimal adjustment particularly when the layout is the traditional sort. (By "traditional" I mean wire dominant with only one or two "feed" bunkers between Home and each wire.) [For the time-being I am also discounting surprise breakouts like attacks to the X-side(s) OTB or extra long runs utilizing unique running paths intended to succeed because they aren't the norm.]
Let's back up and review for a minute. It's easy to confuse the game plan with the breakout. It isn't but it is a big part of the plan. Our first principle is underlined by our strategy--and the core strategy is to control the wide boundaries in order to dominate the interior of the field of play. Our choice of breakout options is dictated by preferred style of offense (Inside/Out or Outside/In) and in any given match how effective our opponent is in countering us. Once our primaries have been achieved our priorities are directed by our goals (Strong Side / Weak Side), our individual roles and the shifting positions of the opponent.
Back to the breakout. There are three other characteristics that give dimension and versatility (unpredictability) to your breakouts and those are; sequencing, lane choices & spacing. Something else worth serious attention is the ability of your players to effectively (accurately) run & gun--or as I prefer, gun & run. I cannot stress how important this is. Any team that can gun & run with confidence has a automatic advantage over a team that can't and they can bring a lot more diversity to their game.